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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPRY2
All Species:
17.27
Human Site:
S125
Identified Species:
38
UniProt:
O43597
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43597
NP_005833.1
315
34688
S125
S
R
S
S
T
R
T
S
T
S
S
S
S
S
E
Chimpanzee
Pan troglodytes
XP_517428
319
35122
A129
S
S
G
S
N
S
S
A
S
S
E
Q
G
L
L
Rhesus Macaque
Macaca mulatta
XP_001090386
613
65978
S423
S
R
S
S
T
R
T
S
T
S
S
S
S
S
E
Dog
Lupus familis
XP_542623
315
34699
S125
S
R
S
S
T
R
T
S
T
S
S
S
S
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9QXV8
315
34605
T125
R
S
S
T
R
T
S
T
S
S
S
S
S
E
Q
Rat
Rattus norvegicus
Q3C2P8
410
46787
D150
D
V
F
T
T
A
T
D
S
S
S
N
S
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510585
619
67001
T429
R
S
S
T
R
T
S
T
S
S
G
S
S
E
H
Chicken
Gallus gallus
Q9PTL2
313
34398
R123
T
G
S
R
S
S
T
R
T
S
T
S
S
N
S
Frog
Xenopus laevis
NP_001082238
314
35083
T124
S
S
R
S
N
T
R
T
S
S
S
S
S
E
Q
Zebra Danio
Brachydanio rerio
Q6NYK3
413
46811
D150
D
V
F
T
T
A
T
D
S
S
S
N
S
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44783
589
62370
L325
G
L
G
L
G
L
G
L
G
L
N
Q
P
I
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.3
48.6
97.1
N.A.
96.5
20.2
N.A.
44.4
85.4
74.2
21
N.A.
23
N.A.
N.A.
N.A.
Protein Similarity:
100
67.7
50.2
97.4
N.A.
97.4
33.9
N.A.
46.8
90.7
81.5
32.2
N.A.
34.1
N.A.
N.A.
N.A.
P-Site Identity:
100
20
100
100
N.A.
33.3
40
N.A.
26.6
40
40
40
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
100
100
N.A.
66.6
66.6
N.A.
53.3
66.6
60
66.6
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
19
0
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
19
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
10
0
0
28
28
% E
% Phe:
0
0
19
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
10
19
0
10
0
10
0
10
0
10
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
10
0
10
0
10
0
10
0
0
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
19
0
0
0
0
0
10
19
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
19
0
0
37
% Q
% Arg:
19
28
10
10
19
28
10
10
0
0
0
0
0
0
0
% R
% Ser:
46
37
55
46
10
19
28
28
55
91
64
64
82
46
10
% S
% Thr:
10
0
0
37
46
28
55
28
37
0
10
0
0
0
0
% T
% Val:
0
19
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _